Computers in Biology and Medicine
Volume 38, Issue 11 , Pages 1140-1151 , November 2008

Tachycardia-induced early afterdepolarizations: Insights into potential ionic mechanisms from computer simulations

  • Ray B. Huffaker

      Affiliations

    • Department of Computer Science, University of California, 405 Hilgard Avenue, Los Angeles, CA 90095-1596, USA
    • ,
  • Richard Samade

      Affiliations

    • Department of Bioengineering, University of California, Los Angeles, USA
    • ,
  • James N. Weiss

      Affiliations

    • Cardiovascular Research Laboratory, Department of Medicine (Cardiology), David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    • ,
  • Boris Kogan

      Affiliations

    • Department of Computer Science, University of California, 405 Hilgard Avenue, Los Angeles, CA 90095-1596, USA
    • Corresponding Author InformationCorresponding author. Tel.: +13108257393; fax: +13108252273.

Received 10 January 2008 ,Accepted 13 August 2008.

References 

  1. Brachmann J, Scherlag BJ, Rosenshtraukh LV, Lazzara R. Bradycardia-dependent triggered activity: relevance to drug-induced multiform ventricular tachycardia. Circulation. 1983;68:846–856
  2. Sicouri S, Antzelevitch C. Afterdepolarizations and triggered activity develop in a select population of cells (M cells) in canine ventricular myocardium: the effects of acetylstrophanthidin and Bay K 8644. Pacing Clin. Electrophysiol. 1991;14(11 Pt. 2):1714–1720
  3. Luo CH, Rudy Y. A dynamic model of the cardiac ventricular action potential. II. Afterdepolarizations, triggered activity, and potentiation. Circ. Res. 1994;74(6):1097–1113
  4. Clancy CE, Rudy Y. Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia. Nature. 1999;400(6744):566–569
  5. Clancy CE, Rudy Y. Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death. Cardiovasc. Res. 2001;50(2):301–313
  6. Tomaselli GF, Zipes DP. What causes sudden death in heart failure?. Circ. Res. 2004;95(8):754–763
  7. Davidenko JM, Cohen L, Goodrow R, Antzelevitch C. Quinidine-induced action potential prolongation, early afterdepolarizations, and triggered activity in canine Purkinje fibers. Effects of stimulation rate, potassium, and magnesium. Circulation. 1989;79(3):674–686
  8. January CT, Riddle JM. Early afterdepolarizations: mechanism of induction and block. A role for L-type Ca2+ current. Circ. Res. 1989;64(5):977–990
  9. Jackman WM, Szabo B, Friday KJ, Margolis PD, Moulton K, Wang X, et al. Ventricular tachyarrhythmias related to early afterdepolarizations and triggered firing: relationship to QT interval prolongation and potential therapeutic role for calcium channel blocking agents. J. Cardiovasc. Electrophysiol. 1990;1:170–195
  10. Volders PG, Vos MA, Szabo B, Sipido KR, de Groot SH, Gorgels AP, et al. Progress in the understanding of cardiac early afterdepolarizations and torsades de pointes: time to revise current concepts. Cardiovasc. Res. 2000;46(3):376–392
  11. Kogan B, Lamp ST, Weiss JN. Role of intracellular Ca dynamics in supporting spiral wave propagation. In:  Bekey G,  Kogan B editor. Modeling and Simulation. Boston/London/Dordrecht: Kluwer Academic Publishers; 2003;p. 177–193
  12. Huffaker R, Lamp ST, Weiss JN, Kogan B. Intracellular calcium cycling, early afterdepolarizations, and reentry in simulated long QT syndrome. Heart Rhythm. 2004;1(4):441–448
  13. Huffaker RB, Weiss JN, Kogan B. Effects of early afterdepolarizations on reentry in cardiac tissue: a simulation study. Am. J. Physiol. Heart Circ. Physiol. 2007;292(6):H3089–H3102
  14. Volders PG, Kulcsar A, Vos MA, Sipido KR, Wellens HJ, Lazzara R, et al. Similarities between early and delayed afterdepolarizations induced by isoproterenol in canine ventricular myocytes. Cardiovasc. Res. 1997;34(2):348–359
  15. Choi BR, Burton F, Salama G. Cytosolic Ca2+ triggers early afterdepolarizations and Torsade de Pointes in rabbit hearts with type 2 long QT syndrome. J. Physiol. 2002;543(Pt. 2):615–631
  16. Wit AL, Rosen MR. Afterdepolarizations and triggered activity: distinction from automaticity as an arrhythmogenic mechanism. In:  Fozzard HA, et al. editor. The Heart and Cardiovascular System. Scientific Foundations. New York: Raven Press; 1992;p. 2113–2163
  17. Takamatsu T, Wier WG. Calcium waves in mammalian heart: quantification of origin, magnitude, waveform, and velocity. FASEB J. 1990;4(5):1519–1525
  18. Cheng H, Lederer MR, Lederer WJ, Cannell MB. Calcium sparks and [Ca2+](i) waves in cardiac myocytes. Am. J. Physiol. Cell Physiol. 1996;39:C148–C159
  19. Chudin E, Goldhaber J, Garfinkel A, Weiss J, Kogan B. Intracellular Ca(2+) dynamics and the stability of ventricular tachycardia. Biophys. J. 1999;77(6):2930–2941
  20. Luo CH, Rudy Y. A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes. Circ. Res. 1994;74(6):1071–1096
  21. Rubart M, Zipes DP. Mechanisms of sudden cardiac death. J. Clin. Invest. 2005;115(9):2305–2315
  22. Lopez-Lopez JR, Shacklock PS, Balke CW, Wier WG. Local calcium transients triggered by single L-type calcium channel currents in cardiac cells. Science. 1995;268(5213):1042–1045
  23. Bassani JW, Yuan W, Bers DM. Fractional SR Ca release is regulated by trigger Ca and SR Ca content in cardiac myocytes. Am. J. Physiol. Cell Physiol. 1995;268(5):C1313–C1319
  24. Bers D. Excitation–Contraction Coupling and Cardiac Contractile Force. second ed.. Boston: Kluwer Academic Publishers; 2001;pp. 294–300
  25. Stern MD, Capogrossi MC, Lakatta EG. Spontaneous calcium release from the sarcoplasmic reticulum in myocardial cells: mechanisms and consequences. Cell Calcium. 1988;9(5–6):247–256
  26. Samade R, Kogan B. Calcium alternans in cardiac cell mathematical models. In: International Conference on Bioinformatics and Computational Biology. Las Vegas, NV: CSREA Press; 2007;
  27. Shiferaw Y, Watanabe MA, Garfinkel A, Weiss JN, Karma A. Model of intracellular calcium cycling in ventricular myocytes. Biophys. J. 2003;85(6):3666–3686
  28. Zeng J, Rudy Y. Early afterdepolarizations in cardiac myocytes: mechanism and rate dependence. Biophys. J. 1995;68(3):949–964
  29. Rudy Y. Modelling and imaging cardiac repolarization abnormalities. J. Intern. Med. 2006;259(1):91–106
  30. Priori SG, Corr PB. Mechanisms underlying early and delayed afterdepolarizations induced by catecholamines. Am. J. Physiol. 1990;258(6 Pt. 2):H1796–H1805
  31. Wehrens XH, Lehnart SE, Marks AR. Intracellular calcium release and cardiac disease. Annu. Rev. Physiol. 2005;67:69–98
  32. Shimizu W, Antzelevitch C. Differential effects of beta-adrenergic agonists and antagonists in LQT1, LQT2 and LQT3 models of the long QT syndrome. J. Am. Coll. Cardiol. 2000;35(3):778–786
  33. Huffaker RB. Tachycardia-induced early afterdepolarizations: Ionic mechanisms and effects on wave propagation in 1, 2, and 3D tissue (Computer Simulation Study). In: Computer Science. Los Angeles, CA: University of California; 2008;p. 137
  34. Antzelevitch C, Sicouri S, Litovsky SH, Lukas A, Krishnan SC, Di Diego JM, et al. Hetergeneity within the ventricular wall. Electrophysiology and pharmacology of epicardial, endnocardial, and M cells. Circ. Res. 1991;69:1427–1449
  35. Katra RP, Pruvot E, Laurita KR. Intracellular calcium handling heterogeneities in intact guinea pig hearts. Am. J. Physiol. Heart Circ. Physiol. 2004;286(2):H648–H656
  36. Pruvot EJ, Katra RP, Rosenbaum DS, Laurita KR. Role of calcium cycling versus restitution in the mechanism of repolarization alternans. Circ. Res. 2004;94(8):1083–1090
  37. Jafri MS, Rice JJ, Winslow RL. Cardiac Ca2+ dynamics: the roles of ryanodine receptor adaptation and sarcoplasmic reticulum load. Biophys. J. 1998;74(3):1149–1168
  38. Samade R, Kogan B. The properties of the cardiac cell mathematical model with the Markovian representation of potassium channel gating processes under high pacing rate (computer simulation study). In: METMBS’04. Las Vegas, NV: CSREA Press; 2004;

PII: S0010-4825(08)00123-6

doi: 10.1016/j.compbiomed.2008.08.010

Computers in Biology and Medicine
Volume 38, Issue 11 , Pages 1140-1151 , November 2008

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